Publications

Home Publications
  • Bellomo G, Rainer C, Quaranta V, Astuti Y, Raymant M, Boyd E, Stafferton R, Campbell F, Ghaneh P, Halloran C, Hammond D, Morton J, Palmer D, Vimalachandran D, Jones R, Mielgo A, Schmid MC. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signaling axis. Gut, 2022
  • Ireland L, Luckett T, Schmid MC, Mielgo A. Blockade of Gas6 alters cancer cell plasticity, activates NK cells and inhibits pancreatic cancer metastasis. Ireland L, Luckett T, Schmid MC, Mielgo A., Feb 2020
  • Mielgo A., Schmid MC. Liver Tropism in Cancer: The Hepatic Metastatic Niche. Cold Spring Harb Perspect Med., 2019
  • Quaranta V., Schmid MC. Macrophage-mediated subversion of anti-tumour immunity. Cells, 2019 Jul
  • Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018 Dec
  • Ireland L, Santos A, Campbell F, Figueiredo C, Hammond D, Ellies LG, Weyer-Czernilofsky U, Bogenrieder T, Schmid MC, Mielgo A. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene. 2018.
  • Quaranta V, Rainer C, Nielsen SR, Raymant ML, Ahmed MS, Engle DD, Taylor A, Murray T, Campbell F, Palmer DH, Tuveson DA, Mielgo A, Schmid MC. Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer. Cancer Res. 2018
  • Figueiredo CR, Azevedo RA, Mousdell S, Resende-Lara PT, Ireland L, Santos A, Girola N, Cunha RLOR, Schmid MC, Polonelli L, Travassos LR, Mielgo A. Blockade of MIF-CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma. Front. Immunol 2018
  • Tanton H, Voronina S, Evans A, Armstrong J, Sutton R, Criddle DN, Haynes  L, Schmid MC, Campbell F, Costello E and Tepikin AV. F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation.  Front. Physiol., 2018
  • Nielsen S and Schmid MC. Macrophages as key drivers of cancer progression and metastasis. Mediators Inflamm. 2017;2017:9624760.
  • Ireland L, Santos A, Ahmed MS, Rainer C, Nielsen SR, Quaranta V, Weyer-Czernilofsky U, Engle DD, Perez-Mancera P, Coupland SE, Taktak AF, Bogenrieder T, Tuveson DA, Campbell F, Schmid MC, Mielgo A. Chemoresistance in pancreatic cancer is driven by stroma-derived insulin-like growth factors. Cancer Research, October 2016.
  • Nielsen S, Quaranta S, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakei T, Sakei K, Kim Y, Engle D, Campbell F, Palmer D, Ko J, Tuveson D, Hirsch E, Mielgo A, Schmid MC. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol. 2016 May;18(5):549-60
  • Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu, X, Karin M, Sasik R, Cohen EEW, Varner JA. PI3Kγ is a molecular switch that controls immune suppression. Nature, Sept, 2016.
  • Kaneda M, Cappello P, Nguyen AV, Ralainirina N, Hardamon C, Fouber P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy A, Valasek M, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3Kγ drives pancreatic ductal adenocarcinoma progression. Cancer Discov. 2016 May 13. Cancer Discovery, May, 2016.
  • Abu-Alainin W, Gana T, Liloglou T, Olayanju A, Barrera LN, Ferguson R, Campbell F, Andrews T, Goldring C, Kitteringham N, Park BK, Nedjadi T, Schmid MC, Slupsky JR, Greenhalf W, Neoptolemos JP, Costello E. UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis J Pathol., 2016 Feb;238(3)
  • Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. PNAS. 2013 May 13.
  • Mielgo A. and Schmid MC. Impact of tumour associated macrophages in pancreatic cancer. BMB Rep. 2013 Mar;46(3):131-8.
  • Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PI3-Kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One. 2013;8(4)
  • Schmid MC and Varner JA. Myeloid cells and tumor inflammation. Vascular Cell, 2012 Sep 3;4(1)14
  • Yuan RT, Young S, Liang J, Schmid MC, Mielgo A, Stupack DG. Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. Apoptosis. 2012 Mar;17(3):229-35
  • Schmid MC, Avraamides CJ, Foubert P, Saked Y, Kang SW, Kerbel R, and Varner JA. Combined blockade of integrin a4b1 plus cytokines SDF-1a or IL-1b potently inhibits tumor inflammation and growth. Cancer Research, 2011 Nov 15;71(22):6965-75
  • Schmid MC, Avraamides CJ, Dippold H, Franco I, Foubert P, Acevedo LM, Ellies LG, Manglicmot J, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field S, and Varner JA. Receptor tyrosine kinases and TLR/IL1R unexpectedly activate myeloid PI3Ky a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14;19(6):715-27.
  • Schmid MC and Varner JA. Myeloid cells in the tumor microenvironment: Modulation of tumor angiogenesis and tumor inflammation. J Oncol. 2010;2010:201026.
  • Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulu, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin α4β1 signaling is required for tumor lymphangiogenesis and metastasis. Cancer Res. 2010 Apr 15;70(8):3042-51.
  • Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, Lee P, Shields DJ, Barbero S, Jamora C, Stupack DG. The death effector domains of caspase-8 induce terminal differentiation. PLoS One. 2009 Nov 18;4(11):e7879.
  • Schmid MC and Varner JA. Methods to study myeloid cell roles in angiogenesis. Methods in Enzymology, Volume 445, Chapter 15, (2008).
  • Schmid MC and Varner JA. Circulating endothelial progenitor cells. 2008 Angiogenesis Protocols.
  • Schmid MC and Varner JA. Myeloid cell trafficking and tumor angiogenesis. 2007 Cancer Lett. 250; 1-8.
  • Schmid MC, Scheidegger F, Dehio M, Balmelle-Deveaux N, Schulein R, Guye P, Chennakesava CS, Biedermann B, Dehio C. A translocated bacterial protein protects vascular endothelial cells from apoptosis. PLoS Pathogens 2006 Nov; 2 (11): e115
  • Schulein R, Guye P, Rhomberg TA, Schmid MC, Schröder G, Vergunst AC, Carena I, Dehio C. A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells. Proc. Natl. Acad. Sci. 2005 Jan 18; 102(3): 856-61
  • Schmid MC, Schulein R, Dehio M, Denecker G, Carena I, Dehio C. The VirB type IV secretion system of Bartonella henselae mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. Mol Microbiol, 2004 Apr; 52(1): 81-92
  • Schmid MC, Bisoffi M, Wetterwald A, Gautschi E, Thalmann GN, Mitola S, Bussolino F, Cecchini MG. Insulin-like growth factor binding protein-3 is overexpressed in endothelial cells of mouse breast tumor vessels. Int J Cancer, 2003 Feb 20; 103(5): 577-86
  • Fuhrmann O, Arvand M, Gohler A, Schmid M, Krull M, Hippenstiel S, Seybold J, Dehio C, Suttorp N. Bartonella henselae induces NF-kappaB-dependent upregulation of adhesion molecules in cultured human endothelial cells: possible role of outer membrane proteins as pathogenic factors. Infect Immun, 2001 Aug; 69(8): 5088-97.
  • Djonov V, Schmid M, Tschanz SA, Burri PH. Intussuceptive Angiogenesis; Its role in embryonic vascular network formation. Circ Res, 2000; 86:286-92.